Clinical drug interactions with food and drink

2021-06-23 03:29 PM

Alcohol can cause interactions with antidepressants and sleeping pills. Alcohol enhances the ulcerative bleeding effect of non-steroidal anti-inflammatory drugs.

Drug interactions with food

Effects of food on medicine

Decreased or delayed absorption of the drug

affect drug metabolism

Change drug excretion

Change the toxicity of the drug

Time to take medicine

Drink when full, time for food to stay in the stomach is 1 - 4 hours. Take the drug on an empty stomach (on an empty stomach) with drugs that are easily destroyed in the acidic environment of the stomach eg digoxin, slow-release drugs to prevent the tablet coating from being destroyed by the acidic environment eg Aspirin pH8, Adalat LP 20 mg...

Therefore, it is necessary to look up the National Pharmacopoeia or read the prescription to know exactly when to give the patient the most appropriate medicine.

Drug and drink interactions

There are some drugs that, when taken at the same time with certain foods and drinks, will cause adverse interactions. When taking drugs through the gastrointestinal tract, the drug is absorbed in the mouth, in the stomach, in the small intestine, in the large intestine, each drug will be stable in a different pH environment. Therefore, it is necessary to guide the patient to eat properly when taking the drug, and at the same time to know to take the drug at a reasonable time: before, after, near and far from a meal.

It is best for the patient to take the medicine with cooled boiled water. The drug should be avoided with:

Milk: All antibiotics are reduced by milk.

Tea: Causing many drugs to precipitate.

Mineral water: High alkalinity causes increased absorption of some drugs.

Alcohol: Alcohol can cause interactions with antidepressants and sleeping pills. Alcohol enhances the ulcerative bleeding effect of non-steroidal anti-inflammatory drugs. Concomitant use of alcohol with antihypertensive drugs causes a sudden drop in blood pressure. Concomitant use of alcohol with isoniazid or metronidazole causes an alcoholic reaction, alcoholic patients will not quit drinking but quit smoking.