Drugs excreted in breast milk

2021-06-26 04:17 PM

Some antihistamines pass into breast milk in large amounts; although the harmful effects are unknown, drug manufacturers recommend not to use; There are reports of children having dizziness and vertigo with clementine.

 

Drugs excreted in breast milk

Amantadine

Avoid use; in breast milk; There are reports of poisoning in breastfed babies

Amphetamine

Into breast milk, a lot should be avoided

Aspirin

Avoid - may increase risk of Reye's syndrome; Frequent use of high doses may cause impaired platelet function and hypoprothrombinaemia in infants if the infant's vitamin K stores are low.

Azithromycin

The manufacturer recommends avoiding use; No other info yet

Barbituric

Avoid use if possible; High doses can cause dizziness

Benzodiazepine

Passes into breast milk - avoid if possible

Captopril

Excreted into breast milk - the manufacturer recommends avoiding

Cephalosporin

Excreted in breast milk at low concentrations

Chloramphenicol

Should use another antibiotic; because it can cause bone marrow toxicity in children; Drug levels in breast milk are usually not enough to cause gray syndrome.

Ciprofloxacin

Avoid - high concentrations in breast milk mẹ

Corticosteroid

Continuous treatment with high doses (>10mg of prednisolone per day) may harm the child's adrenal function - careful monitoring is required.

Co-trimoxazole

There is a low risk of kernicterus in children with jaundice and a low risk of hemolysis in children with G6PD deficiency (due to sulphathiazole).

Cyclophosphamide

Stop breastfeeding during treatment and 36 hours after treatment

Diclofenac

Too small amount is not harmful enough

Ephedrine

There are reports of stimulant effects and poor sleep

Ergotamine

Avoid use; Possibility of ergotin toxicity in infants, repeated doses may cause inhibition of lactation

Erythromycin

Only small amounts are found in breast milk

Ibuprofen

Too small of a drug is not harmful enough, but some manufacturers recommend avoiding it (including topical use).

Indomethacin

The amount of drug that enters breast milk may be too small to cause harm, but seizures have been reported in one infant. Manufacturers recommend avoiding use

Iodine

Stop breastfeeding; risk of hypothyroidism or neonatal goitre; drug concentration in breast milk

Radioactive Iodine

Breastfeeding is contraindicated after taking therapeutic doses. For diagnostic doses, discontinue breastfeeding for at least 24 hours

Isoniazid

Monitor children for possible drug poisoning; theoretical risk of seizures and neurological disease; Prophylactic pyridoxine is recommended for both mother and child

Isotretinoin

Avoid using

Ketoconazole

Manufacturers recommend avoiding the use

The mixture of cough medicine containing iodide

It is recommended to use cough medicine mixtures

Metronidazole

In large amounts in breast milk, The manufacturer recommends avoiding high single doses

Morphine

The therapeutic dose has no effect on the child; with drug-dependent mothers with withdrawal symptoms; Breastfeeding is not the best way to treat drug dependence in your baby and should be stopped

Nicotine

Avoid using because it is in breast milk

Nitrofurantoin

Only small amounts pass into breast milk but may be sufficient to cause haemolysis in infants with G6PD deficiency

Norfloxacin

No information yet - the manufacturer recommends avoiding

Oestrogen

Avoid use; Adverse effects of drugs on lactation

Paracetamol

The amount of medicine in breast milk is too small to cause harm

Penicillin

Monitor the amount of medicine in milk

Rifampicin

The amount of medicine in breast milk is too small to cause harm

Alcohol

Large quantities can adversely affect children and reduce milk consumption

Sulphonylureas

Use caution; theoretically capable of lowering blood glucose in children

Tetracycline

Avoid (although osmotic and thus cause enamel loss in children that can be prevented by incorporating calcium in milk)

Theophylline

Notice of irritation in children; Modified-release preparations may be safe

Beta-blockers and labetalol

Monitor children; there may be drug toxicity due to beta-blockers, but the majority of beta-blockers when taken in breast milk are small, so there is no harm to the baby; the drugs acebutolol, atenolol, nadolol, and sotalol are present in breast milk in greater amounts than other beta-blockers; The manufacturer recommends avoiding celiprolol

Oral anticoagulants

Increased risk of bleeding due to vitamin K deficiency; warfarin is safe but phenindione should be avoided; dicoumarol manufacturer recommends vitamin K prophylaxis for children (refer to product documentation)

Antihistamines

Some antihistamines pass into breast milk in large amounts; although the harmful effects are unknown, drug manufacturers recommend not to use; There are reports of children having dizziness and vertigo with clementine.

Contraceptive pills, oral

Avoid taking birth control pills for 6 months or until weaning

Tinidazole

Is present in breast milk. The manufacturer recommends against breastfeeding during and for 3 days after stopping treatment

Tretinoin

Avoid using

Vancomycin

Found in milk. The manufacturer recommends avoiding the use

Vitamin A

Theoretically, there is a risk of drug poisoning in the child when the mother takes high doses of the drug

Vitamin D (and related compounds)

Caution with high doses; May cause hypercalcemia in children

Some new drugs will be updated.