Lecture of Bowen's disease

2021-03-24 12:00 AM

Decisive diagnosis: based on clinical and histopathology (strawberry-shaped dendritic cells with vacuoles called Bowen cells or Darier keratinocytes).

Outline

A rare disease described by Bowen in 1912 as a precancerous keratosis.

Clinical symptoms

The disease occurs in middle-aged people or in the elderly, anywhere on the skin or mucous membranes (genitals and mouth). Lesions on the skin are solitary disc-shaped patches or 10 to 20 clusters. The patches are dark brown or pink with slightly high edges, flat, small like duckweed or wide array, with quite clear arc. The lesions are also concave in the centre, rough around with spines like rice seeds, covered with skin scales and secretions.

Bowen disease progresses through 2 stages: the first stage is 3 - 10 years, the damage is relatively stable. In the later stage, the clumps of lesions become slippery, ulcerated, and warped, very similar to dendritic cancer.

Decision diagnosis and differential diagnosis

Decisive diagnosis: based on clinical and histopathology (strawberry-shaped dendritic cells with vacuoles called Bowen cells or Darier keratinocytes).

Differential diagnosis: with psoriasis, red lupus, oily rice seeds, syphilis III, tuberculosis like rice seeds, rice seed lichen ...

Treatment

The early stage of cold burning, deep-burning has good results. In the late stage, the lesions are removed by surgery, radiotherapy.