Lecture of the fungus Penicilliosis

2021-02-05 12:00 AM

Just as dimorphic fungi can cause systemic radiculopathy in HIV patients, the fungus causes dermatitis, resulting in a popular nodule in the skin resembling histoplasmosis.

Leaven

Caused by some penicillium species such as P. minatum; P. citrorosum;

leagues; P.glaucum; P.album; P.mucedo; P.racemosus; P.exitrosus ... often causes inflammation of the skin, nails, ear infections, respiratory tract, lungs.

More recently, the Penicillium marneffei is more common in HIV / AIDS-infected patients and is named emerging pathogens, an emerging pathogens, a dimorphism, isolated for the first time. It is a species of liver damage in bamboo mice (Rhizomes Sinensis), a very common animal in Southeast Asia. Usually, this fungus causes little disease, but it is emerging to cause disease in people infected with HIV, especially AIDS. The disease is common in Southeast Asia, recently there were case reports in south China, Hong Kong, Laos, Indonesia ...

Clinical symptoms

Just as dimorphic fungi can cause systemic radiculopathy in HIV patients, the fungus causes dermatitis, resulting in a popular nodule in the skin resembling histoplasmosis. In susceptible individuals to fungal infections, fever, weight loss, lymphadenopathy, enlarged liver, enlarged spleen, dyspnoea, cough, pericarditis, and peritonitis may occur.

Lesions to the skin and muscles may also develop molluscum-like papules, pustular acne, lumps, seeds, ulcers and subcutaneous abscesses.

Diagnostic tests

Marneffe is a dimorphic fungus, with different appearance when cultured at different temperatures.

At 37 ° C or in the organism: fungi are oval-shaped yeasts (in tissue cells and macrophages), very special germination cells have a central septum, which is the difference between fungi. real yeast.

Inoculation on savoured medium at 25 ° C, the colonies are initially almost Gray powder, then yellowish-green or pink-Gray in colour, the lower surface of the colony has a red diffusing colour into the medium. When examined under the microscope, on the mycelium with a septum, spores will form on a bottle-shaped stalk.

This fungus is highly toxic and can cause disease in the laboratory, so one should be aware of this fungus contamination.

Differential diagnosis

needs differential diagnosis with other melasma, popular papules, and skin tuberculosis.

Treatment

When an acute infection can use amphotericin B. However, itraconazole and ketoconazole can also be used effectively. Itraconazole can be used for maintenance therapy.