Pred Forte: Medicine for eye inflammation keratitis

2021-06-21 03:29 AM

Pred Forte is a glucocorticoid, used to treat steroid-responsive inflammation in blepharitis and ocular conjunctivitis, keratitis, and anterior segment of the eyeball.

Producer

Allergan.

Ingredient

Per mL: Prednisolone acetate 10mg.

Pharmacodynamic

Prednisolone acetate is a glucocorticoid that, on a weight basis, is 3 to 5 times more anti-inflammatory than hydrocortisone. Glucocorticoids have inhibitory effects on edema, fibrin deposition, capillary dilation, and phagocytosis in acute inflammation, also have a good response on capillary proliferation, collagen deposition, and scarring.

Pharmacokinetics

No data yet.

Indications and uses

Steroid-responsive inflammation in blepharitis and ocular conjunctivitis, keratitis, and anterior segment of the eyeball.

Dosage and Administration

Eye drops.

Instill 1 to 2 drops into the conjunctival sac 2 to 4 times a day. During the first 24 to 48 hours, the dose may be increased to 2 drops per hour.

Note that the drug should not be stopped early.

Use caution

Long-term or high-dose corticosteroid use has been reported to cause posterior subcapsular cataracts.

Caution should be exercised in the treatment of patients with a history of herpetic keratitis.

Warning

For diseases that cause corneal thinning, corneal perforation has been reported with topical steroid use. Prolonged use of topical corticosteroids has been implicated in thinning of the cornea and sclera. The use of topical corticosteroids in cases of thinning of the cornea and sclera may lead to perforation.

Because Pred Forte does not contain antibacterial active ingredients, appropriate treatment must be selected if there is an infection.

Acute or untreated purulent eye infections may be masked or exacerbated by topical steroid use, and prolonged use may decrease the immune response in ocular tissue cells, thereby increased the chance of secondary infection.

Intraocular steroid use may prolong therapy and worsen many viral eye infections (including Herpes simplex). Extreme caution should be taken when administering steroids to patients with a history of Herpes simplex infection and frequent, mandatory slit-lamp microscopy monitoring.

Coincidentally, fungal infection of the cornea has been reported with long-term topical steroid use. treatment with steroids. Fungal culture should be performed when appropriate.

Prolonged use of topical corticosteroids may increase intraocular pressure in susceptible individuals. This can lead to glaucoma, damage to the optic nerve, and vision and field defects. Steroids should be used with caution in the presence of glaucoma. Eye pressure should be checked regularly, especially in patients with a history of or current glaucoma.

The possibility of adrenal suppression should be considered with frequent, prolonged high-dose topical steroid use, especially in infants and children.

Corticosteroid-containing eye drops should not be used for more than 10 days, except under strict eye supervision and frequent monitoring of intraocular pressure.

The preservative benzalkonium chloride in Pred Forte can be absorbed and discolor soft contact lenses. Patients who wear soft contact lenses should be instructed to remove their contact lenses before using this suspension and to wait at least 15 minutes after instilling Pred Forte when reinserting soft contact lenses.10. To prevent eye damage or contamination, care should be taken to prevent the tip of the vial or tube from touching the eye or any other surface. Using the vial or tube of medicine by more than one person can spread the infection. Keep the vial or tube tightly closed when not in use.

If signs and symptoms do not improve after 2 days, the patient should be reevaluated.

The safety and effectiveness of corticosteroids in children have not been established.

No overall differences in safety or efficacy were observed between elderly and younger patients.

Overdose

An overdose of topical medication in the eye does not usually cause acute problems. If accidentally swallowed, drink water to dilute the medicine.

Contraindications

Untreated purulent eye infections, superficial (or epithelial) keratitis caused by Herpes simplex (dendritic keratitis), smallpox, chickenpox, and most other viral infections of the cornea and conjunctivitis, Mycobacterium infections such as ocular tuberculosis, mycosis of the ocular structures and hypersensitivity to any component of the drug.

Interactive

No data yet.

Side effects

Causes glaucoma with damage to the optic nerve decreased visual field. May also cause posterior subcapsular cataracts; secondary infections caused by fungi or viruses released from the eye tissue; eyeball perforation when used in case of thinning of the cornea or sclera; slow wound healing. Corticosteroid-containing preparations are the cause of acute anterior vasculitis or perforation of the globe. Mydriasis, amblyopia, and ptosis have rarely occurred with topical corticosteroids. Some systemic side effects can occur with high doses of steroids. Rare cases of systemic toxicity due to corticosteroid overdose have been reported following topical steroid administration.

The following adverse events have been identified during the post-approval use of Pred Forte. Because these effects are reported voluntarily from a population of undetermined size, it is not always possible to reliably estimate the frequency of these effects or establish a causal relationship with drug use.

Immune system disorders: Hypersensitivity, urticaria.

Nervous system disorders: Headache.

Eye disorders: Posterior subcapsular cataract, eye irritation, eye puncture (perforation of the sclera or cornea), foreign body sensation in the eye, glaucoma, dilated pupils, eye congestion, infection eyes (including bacterial, fungal, and viral infections), blurred vision/visual disturbances.

Digestive disorders: Taste disturbance.

Skin and subcutaneous tissue disorders: Pruritus, rash.

Caution

Subcapsular cataracts have been reported following prolonged and high-dose topical corticosteroid use in ophthalmology. Acute anterior fasciitis may occur in susceptible individuals.

The use of steroids after cataract surgery can slow wound healing and increase the chance of herpes infection. If signs of hypersensitivity or serious reactions occur, discontinue use immediately. Cross-sensitization among corticosteroids has been adequately demonstrated.

After instillation, patients may experience transient blurred vision, which may impair the ability to drive or operate machinery. If affected, the patient should not drive or operate machinery until clear vision is restored.

Preservation

Store at a temperature between 15°-25°C. Hold the vial in an upright position. Avoid freezing.

Presentation and packaging

Eye drop suspension: 5mL vial.