Xenazine (Huntington treatment drug information)

2021-07-01 04:20 PM

Do not use Xenazine if you have used an MAO inhibitor in the past 14 days. Dangerous drug interactions can occur. MAO inhibitors including isocarboxazid, linezolid, methylene blue, phenelzine

Generic Name: Tetrabenazine.

Brand: Xenazine.

What is Xenazine?

Xenazine (tetrabenazine) reduces the amount of a chemical in the body in people with Huntington's disease.

Xenazine is used to treat Huntington's chorea (uncontrolled muscle movements).

Xenazine may also be used for purposes not listed in this medication guide.

Important Information

Xenazine should not be used if you have severe or untreated depression, suicidal thoughts, liver disease, or if you have taken reserpine in the past 20 days.

You may experience depression or thoughts of suicide while taking this medicine. Be on the lookout for mood swings or symptoms. Report any new or worsening symptoms to your doctor.

Do not use Xenazine if you have used an MAO inhibitor in the past 14 days. Dangerous drug interactions can occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

Stop taking Xenazine and call your doctor right away if you have any new or worsening symptoms such as altered mood or behavior, confusion, trouble swallowing, problems with balance, uncontrollable muscle movements, extremely sleepy, or if you feel restless, agitated, hyperactive (mentally or physically), depressed, or have thoughts about suicide or hurting yourself.

Before taking Xenazine

Xenazine should not be used if you are allergic to tetrabenazine, or if you have:

Severe or untreated depression;

Suicidal thoughts;

Liver failure; or

If you have taken reserpine in the past 20 days.

Do not use Xenazine if you have used an MAO inhibitor in the past 14 days. Dangerous drug interactions can occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

To make sure Xenazine is safe, tell your doctor if you have:

Depression, emotional disturbance, or mental illness;

History of suicidal thoughts or actions;

Past or present breast cancer;

Heart disease or arrhythmia;

Personal or family history of long QT syndrome; or

Recently had a heart attack.

Taking Xenazine may increase your risk of depression or thoughts about suicide. Your doctor will check your progress at regular visits. Family or other caregivers should also be on the lookout for changes in mood or symptoms.

It is not known whether Xenazine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether tetrabenazine passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

How should I use Xenazine?

Take Xenazine exactly as prescribed by your doctor. Follow all directions on the medication label. Your doctor may sometimes change your dose to ensure the best results. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Xenazine can be taken with or without food.

Call your doctor if symptoms do not improve, or if they get worse.

Xenazine should not be stopped suddenly or symptoms may return. Talk to your doctor before stopping taking this medicine.

Store at room temperature away from moisture and heat.

Xenazine quantitative information

Usual Adult Dose for Huntington's Disease:

Initial dose: First week: 12.5 mg orally daily, in the second week: 12.5 mg orally 2 times daily.

Maintenance dose: Titrate with 12.5 mg orally weekly to a tolerated dose that reduces chorea - maximum dose: 37.5-50 mg daily should be given in 3 divided doses, maximum recommended dose times: 25 mg.

What happens if a dose is missed?

Take that dose as soon as you remember. Skip the missed dose if it is almost time for the next scheduled dose. Do not take extra medicine to make up for the missed dose.

If you miss a dose for more than 5 days in a row, ask your doctor before starting Xenazine again.

What happens if you overdose?

Seek emergency medical attention.

What should be avoided while taking Xenazine?

This medicine may decrease thinking or reactions. Be careful if you drive or do anything that requires a warning.

Drinking alcohol with this medicine can cause side effects.

Xenazine side effects

Get emergency medical help if you have signs of an allergic reaction to Xenazine: hives; shortness of breath; swelling of the face, lips, tongue, or throat.

Report any new problems or symptoms to your doctor, such as worsening: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if feeling impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or having thoughts about suicide or hurting yourself.

Call your doctor right away if you have:

Tremors, tremors, restless movements, problems with balance;

Uncontrollable facial muscle movements (chewing, lip-smacking, frowning, tongue movements, blinking or eye movements);

Difficulty swallowing;

Fast or irregular heartbeat;

Feeling delirious; or

Severe nervous system reaction--muscle stiffness, high fever, sweating, confusion, fast or irregular heartbeat.

Common Xenazine side effects may include:

Drowsiness, fatigue;

Depressed mood;

Nausea; or

Feeling anxious, agitated, or restless.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

What other drugs will affect Xenazine?

Other drugs may interact with tetrabenazine, including prescription and nonprescription drugs, vitamins, and herbal products. Tell each health care provider about all medicines you take now and any medicines you start or stop using.