Chronic kidney disease: often associated with irreversible impairment of kidney function
In general, chronic kidney disease, like acute kidney damage, can result from damage that starts in the renal vascular system, glomeruli, tubules, interstitial organization, or low urinary tract.
Chronic kidney disease is defined as kidney damage or impairment that persists for at least 3 months.
Chronic kidney disease is often associated with progression and irreversible loss of large numbers of functional nephrons.
Typical clinical symptoms do not usually occur until the number of functional nephrons falls below 70-75% of normal. In fact, blood electrolyte concentrations and body fluids can remain nearly normal until the number of functional nephrons falls below 20-25% of normal.
Board. Several causes of acute kidney damage to the kidneys
* Damage to small vessels and/or glomeruli
Vasculitis (inflammation of multiple nodules)
* Tubular epithelial injury (tubular necrosis)
Acute tubular necrosis due to ischemia
Acute tubular necrosis caused by toxins (heavy metals, ethylene glycol, insecticides, poisonous fungi, carbon tetrachloride)
* Damage to the kidneys
Interstitial nephritis due to acute allergies.
The table lists some of the main causes of chronic kidney disease. In general, chronic kidney disease, like acute kidney damage, can result from damage that starts in the renal vascular system, glomeruli, tubules, interstitial organization, or low urinary tract. Although there are a large number of non-kidney diseases that can lead to chronic kidney disease, the end result is the same - a decrease in the number of functional nephrons.