Sodium channel blockers: decrease the reabsorption of sodium in the manifold

2021-05-06 02:04 PM

A decrease in the activity of the sodium-potassium-ATP pump reduces potassium transport into the cells and thereby reduces the excretion of potassium into the tubular lumen. For this reason, sodium channel blockers are also called potassium-sparing diuretics and decrease the rate of potassium excretion in the urine.

Amiloride and triamterene also inhibit sodium reabsorption and potassium excretion in the manifold, similar to the mechanism of spironolactone. However, at the cellular level, these drugs act directly to prevent sodium from entering sodium channels in the inner membrane of the colliostoma. Because this reduces sodium entering the epithelial cells, it also reduces sodium transport through the outer membrane of the cell and thus reduces the sodium-potassium-ATP pump activity.

Figure. The amount of sodium excreted and extracellular fluid flow during diuretics. An increase in urinary sodium excretion is accompanied by a decrease in extracellular fluid volume. If the amount of sodium is eliminated continuously, there will be a compensatory mechanism to bring the sodium excreted back to balance with the sodium intake into the body, the sodium balance in the body will be reset.

A decrease in the activity of the sodium-potassium-ATP pump reduces potassium transport into the cells and thereby reduces the excretion of potassium into the tubular lumen. For this reason, sodium channel blockers are also called potassium-sparing diuretics and decrease the rate of potassium excretion in the urine.

Board. Classification of diuretics, mechanism of action and location of action on the renal tubules.

 

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