Cirrhosis

2021-02-22 12:00 AM

Cirrhosis is an end-stage liver disease characterized by disruption of the liver architecture by bands of fibrosis which divide the liver into nodules of regenerating liver parenchyma.

CIRRHOSIS

Cirrhosis is end- stage liver disease characterized by disruption of the liver architecture by bands of fibrosis which divide the liver into nodules of regenerating liver parenchyma.

Causes of cirrhosis include alcohol, viral hepatitis, biliary tract disease, hemochromatosis, cryptogenic/idiopathic, Wilson disease, and α-1-antitrypsin deficiency.

On gross Pathology, micronodular cirrhosis has nodules <3 mm, while macronodular cirrhosis has nodules >3 mm; mixed micronodular and macronodular cirrhosis can also occur. At the end stage, most diseases result in a mixed pattern, and the etiology may not be distinguished based on the appearance.

Cirrhosis has a multitude of consequences, including portal hypertension, asci-tes, splenomegaly/hypersplenism, oesophagal varices, hemorrhoids, caput medusa, decreased detoxification, hepatic encephalopathy, spider angiomata, palmar ery-thema, gynecomastia, decreased synthesic function, hepatorenal syndrome and coagulopathy.