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Composition of Amyloid
2021-02-24 12:00 AM
An amyloidosis is a group of diseases characterized by the deposition of an extracellular protein that has specific properties.
COMPOSITION OF AMYLOID
An amyloidosis is a group of diseases characterized by the deposition of an extracellular protein that has specific properties.
- Individual molecular subunits form β-pleated sheets. Amorphous eosinophilic extracellular deposits of amyloid are seen on the H&E stain. These deposits stain red with the Congo red stain, and apple green birefringence of the amyloid is seen on the Congo red stain under polarized light.
- The fibrillary protein of amyloid varies with each disease. Also present in amyloid are serum amyloid P (SAP) and glycosaminoglycans (heparan sulfate).