Composition of Amyloid

2021-02-24 12:00 AM

An amyloidosis is a group of diseases characterized by the deposition of an extracellular protein that has specific properties.

COMPOSITION OF AMYLOID

An amyloidosis is a group of diseases characterized by the deposition of an extracellular protein that has specific properties.

  • Individual molecular subunits form β-pleated sheets. Amorphous eosinophilic extracellular deposits of amyloid are seen on the H&E stain. These deposits stain red with the Congo red stain, and apple green birefringence of the amyloid is seen on the Congo red stain under polarized light.
  •  The fibrillary protein of amyloid varies with each disease. Also present in amyloid are serum amyloid P (SAP) and glycosaminoglycans (heparan sulfate).