Genomic Imprinting

2021-02-24 12:00 AM

Genomic imprinting refers to the differential expression of genes based on chromo-somal inheritance from maternal versus paternal origin.

GENOMIC IMPRINTING

Genomic imprinting refers to the differential expression of genes based on chromo-somal inheritance from maternal versus paternal origin.

  • In Prader-Willi syndrome, microdeletion on paternal chromosome 15 {del(15) (q11;q13)} causes intellectual disability, obesity, hypogonadism, and hypotonia.
  •  In Angelman syndrome, microdeletion on maternal chromosome 15 {del(15) (q11;q13)} causes intellectual disability, seizures, ataxia, and inappropriate laughter.