Use of progestin in obstetrics and gynecology

2021-03-18 12:00 AM

To help develop and increase the physiological activity of the uterus as well as of the uterine lining, natural progestins such as progesterone, or almost natural ones such as 17-hydroxyprogesterone are used.

Effects of progestins (including progesterone)

Limiting the development of uterine muscles, especially the fibroids of the uterus, should be used to treat or slow down uterine fibroids in the case of small fibroids.

Reduces the sensitivity of the uterine muscles to contraction factors, which can be used in pregnancy.

Uterine atrophy and can be used to treat cancer of the uterus lining or uterine cancer metastases that surgery cannot reach.

Combining with estrogen in the case has been prepared with estrogen as the uterine mucosa secretes so it can be used to treat infertility, helping the quadrilateral mucosa prepare to nest for eggs. It can also be used in the artificial menstrual cycle in the second half of the menstrual cycle.

Inhibition of cervical mucus secretion, applicable to contraception.

Atrophy of the mammary glands can be used in the treatment of fibroids or enlarged mammary glands.

Has diuretic properties, reduces oedema, and can be used in the treatment of pre-menstrual oedema.

To help develop and increase the physiological activity of the uterus as well as of the uterine lining, natural progestins such as progesterone, or almost natural, 17-hydroxyprogesterone are used. Also want to use with inhibitory properties, people often use semi-synthetic progestin 19-nor testosterone origin. Progesterone-derived substances include progesterone (Lutogyl, Utrogestan, progesterone retard), Chlormadinone acetate (Lutheran), dydrogesterone (Duphaston), medroxyprogesterone acid (Dcpo-Provera megestrol), nomegestrol acctat (Lutenyl). Substances derived from the 19-nor-testosterone commonly used include lynestrenol (Orgamctril), norgestrel (Postinor), allylestrenol (turinal), etynodiol diacetate (Lutometrodiol).

Contribute to the artificial menstrual cycle

After giving estrogen in the first half of the expected menstrual cycle, progestin is administered in the second half along with estrogen.

Estrogen can be given from days 1 to 24, and then from days 13-24 with one of the following progestins:

Duphaston 10mg 1 tablet daily.

Lutometrodriol 2mg 2 tablets daily.

Orgametril 5mg per day 2 Lutenyl 5mg tablets daily with 1 tablet.

Helps the uterine lining to secrete and treat infertility

May be carried out in the manner of amenorrhea in case of amenorrhea.

If there is a normal period, there is only luteal insufficiency:

Progesterone-Retard 250mg 1 ampoule intramuscularly on day 16 of the menstrual cycle.

Duphaston 10mg orally 1-2 capsules daily from day 16-25 of the menstrual cycle.

Utrogestan 100mg x 2-3 capsules daily vaginally for 10 days from day 16 of the menstrual cycle.

Treatment of overplasia of the uterine lining

Lutenyl 5mg per day 1 tablet for 10 days, from day 16 of the menstrual cycle.

Treat premenstrual tension

Utrogestan l100mg daily to take 2-3 pills for 10 days, from day 17 of the menstrual cycle.

Treatment of neuromuscular function

From day 16 of your period, take one of the following medications:

Lutenyl 5mg per day orally 1 tablet.

Duphaston 10mg 1 tablet daily.

Treatment of breast pain

From the 16th - 25th of the cycle use one of the following projects:

Lutenyl 5mg per day orally 1 tablet.

Orgametril 5mg daily take 1-2 capsules.

Treatment of endometriosis

Drink continuously every day for 6-12 periods according to one of the following options:

Duphaston 10mg daily 2-3 tablets.

Luteran 2mg daily 1-5 tablets.

Lutometrodiol 2mg per day 2 tablets.

Treatment of menorrhagia

While menstruating, you can use one of the following ways:

Progesterone 25mg per day intramuscularly 1 ampoule until bleeding is stopped.

Duphaston 10mg a day orally 2-3 tablets until bleeding stops.

If more than 6 days of use as above without banning blood, then change to another method, using estrogen or estrogen in combination with progestin.

Prevent menorrhagia in the following menstrual cycle, use from the 16th - 25th of the menstrual cycle one of the ways:

Lutenyl 5mg per day 1 tablet.

Luteran 2mg per day 2 - 5 tablets.

Lutometrodiol 2mg daily 2-4 tablets.

Combination oral contraceptive pills can also be used.

Use in contraception

Depo-Provera 150mg intramuscularly for 3-month contraceptive effect.

Noristerat 200mg intramuscularly has a 2-month contraceptive effect.

Lynestrenol (Exluton is a brand name currently available in Vietnam) 0.5mg taken daily continuously even during menstruation.

Treatment of threatened miscarriage and preterm birth

One of the following options can be used:

Progesterone minimum dose 25mg / day intramuscularly. Clinical monitoring and endocrine vaginal cells, as long as not stable, do not stop injecting.

Progesterone-Retard (hydroxyprogesterone) 250-500mg per day intramuscularly 1 ampoule until the end of threat, reduce dose to 1 or 2 injections per week.

Utrogestan 100mg per day 2 - 4 capsules, spread evenly throughout the day.

Duphaston 10mg daily orally 3 tablets divided equally throughout the day.

Turinal 5mg orally 1 - 3 tablets daily until symptoms disappear.

Treatment of recurrent miscarriages

Progesterone-Retard 500mg per week intramuscularly as soon as the pregnancy is detected.

Treatment of cancer of the uterine lining

Use of progestin in cancer of the uterus that is not surgical capable:

Depo-Provera 150mg per week injected with one ampoule into the salve.

Contraindicated with progestin

Progestin should not be used in the following cases:

Thrombophlebitis (thrombophlebitis, inflammation of the arteries).

Cardiovascular disease (heart valve disease, hypertension, coronary artery disease ...).

The ear donates cerebral vessels. Breast and uterine cancer.

Pituitary tumour.