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Paediatrics: Chronic inflammatory disorders
Poor growth and short stature is a common feature of long-term inflammatory conditions such as inflammatory bowel disease and rheumatic disorders.
Chronic inflammatory disorders
Poor growth and short stature is a common feature of long-term inflammatory conditions such as inflammatory bowel disease and rheumatic disorders. It may be a presenting feature in Crohn’s disease when GI symptoms are initially minimal.
Short stature is due to long-term use of immunosuppressive agents (e.g.
corticosteroids) and to the generation of inflammatory factors (e.g. IL-6).
Both lead to GH/IGF-I resistance and suppression of bone growth.
Management should be aimed at minimizing inflammation and reducing immunosuppressive therapy. rhGH may have a role in treatment.