Cyclic paralysis in endocrine disease: symptoms and causes

Describe

Cyclic paralysis occurs in waves of painless muscle weakness that often occur suddenly and remain conscious. More root muscles are affected than the apical muscles, reflexes are reduced or lost. Cyclic paralysis is associated with hypokalemia.

Causes

Hyperthyroidism.

Congenital - majority.

Figure. Mechanism of cyclic paralysis in thyroid patients

Mechanism

The lack of ion channels in the muscles is a core cause of cyclic thyrotoxicosis, although the reason and how it happens is unclear.

Hyperthyroidism increases the activity of the Na + / K + pump in muscle cells, resulting in a large and rapid change in intracellular potassium concentration and leads to hyperpolarization and no depolarization in muscle cells.

Meaning

This is a rare sign, causing disease with rates from 2% to 20%, and 0.1%, 0.2% of population order in Asia and America. There was no correlation between the severity of hyperthyroidism and the clinical manifestation of paralysis

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